Frink studied at the Guildford School of Art (now the University for the Creative Arts) (1946–1949), under Willi Soukop, and at the Chelsea School of Art (1949–1953). She was part of a postwar group of British sculptors, dubbed the Geometry of Fear school, that included Reg Butler, Bernard Meadows, Kenneth Armitage and Eduardo Paolozzi.Frink's subject matter included men, birds, dogs, horses and religious motifs, but very seldom any female forms. Bird (1952; London, Tate), one of a number of bird sculptures, and her first successful pieces (also Three Heads and the Figurative Tradition) with its alert, menacing stance, characterizes her early work.She created a bookrest in the form of an eagle, for the lectern of the new Coventry Cathedral, as well as a canopy for its Bishop's throne.
Although she made many drawings and prints, she is best known for her bronze outdoor sculpture, which has a distinctive cut and worked surface. This is created by her adding plaster to an armature, which she then worked back into with a chisel and surform.This process contradicts the very essence of "modeling form" established in the modeling tradition and defined by Rodin's handling of clay.
In the 1960s Frink's continuing fascination with the human form was evident in a series of falling figures and winged men. While living in France from 1967 to 1970, she began a series of threatening, monumental male heads, known as the goggled heads. On returning to England, she focused on the male nude, barrel-chested, with mask-like features, attenuated limbs and a pitted surface, for example Running Man (1976; Pittsburgh, PA, Carnegie Mus. A.). Frink's sculpture, and her lithographs and etchings created as book illustrations, drew on archetypes expressing masculine strength, struggle and aggression. In 1984 she explained that she "focused on the male because to me he is a subtle combination of sensuality and strength with vulnerability".
Frink kept up a hectic pace of sculpting and exhibiting until early 1991, when an operation for cancer of the oesophagus caused an enforced break. However, short weeks later Frink was again creating sculptures and preparing for solo exhibitions. In September, she underwent further surgery. Again, Frink did not let this hold her back, proceeding with a planned trip for exhibitions to New Orleans, Louisiana, and New York City. The exhibitions were a success, but Frink's health was clearly deteriorating. Despite this, she was working on a colossal statue, Risen Christ, for Liverpool Cathedral.This sculpture would prove to be her last; just one week after its installation, Frink died from cancer on 18 April 1993, aged 62, in Blandford Forum, Dorset. Stephen Gardiner, Frink's official biographer, argued that this final sculpture was appropriate: "This awesome work, beautiful, clear and commanding, a vivid mirror-image of the artist's mind and spirit, created against fearful odds, was a perfect memorial for a remarkable great individual."